In a reaction vessel salicylic acid, acetic anhydride and sulfuric acid are mixed. The exothermic reaction will cause the temperature to increase to 70-80°C. Once the reaction is complete the vessel is cooled in an ice bath and the acetylsalicylic acid crystallizes out. This material is re-crystallized in toluene to purify the product. The product identity is confirmed by melting point. The mass of the re-crystallized product is used to determine the yield of the synthesis. In this experiment, we will perform the synthesis of acetylsalicylic acid (aspirin), purification by re-crystallization and use melting point to confirm identity.
2 x 25mL Acetic Anhydride
1 x 15g Salicylic Acid
2 x 25mL Sulfuric Acid Concentrate
2 x 25mL Toluene
Small quantity exemption 173.4
THIS PACKAGE CONFORMS TO 49 CFR 173.4 for domestic highway or rail transport only
WARNING: This product can expose you to chemicals including Strong inorganic acid mists containing sulfuric acid and Toluene, which are known to the State of California to cause cancer and reproductive harm. For more information go to http://www.P65Warnings.ca.gov.